舌鳞癌侵润和转移的相关病理因素分析及临床意义

Pathological analysis and clinical importance of invasion and neck nodal metastasis in squamous cell carcinoma of the tongue

为研究舌鳞癌侵润和颈淋巴结转移因素对肿瘤预后的影响，作者对９２例舌鳞癌诸多病理因素经ＳＰＳＳ／ＰＣ＋数据分析软件处理，结果显示：单因素分析，肿瘤侵润方式（ＭＩ）、癌周侵润淋巴细胞密度（ＰＬＩＤ）、Ｔ分期和病理分级与颈淋巴结转移差异有极显著性（Ｐ＜０．００１）。多因素分析只有ＭＩ和ＰＬＩＤ差异有显著性（Ｐ＜０．０１）。在与侵润方式相关的因素分析中，单因素分析、Ｔ分期、病理分级和ＰＬＩＤ与ＭＩ差异有显著性，多因素分析仅Ｔ分期Ｐ＝０．０４５。ＭＩ和ＰＬＩＤ是与颈淋巴结转移相关的重要因素，Ｔ分期与ＭＩ相关。

To determine the absolute and relative of histopathological parameters and conventional indicators in correlation with invasion and nodal metastasis, we performed both univariate and multivariate statistical analysis in 92 patients with squamous cell carcinoma of the tongue by spss/pc+ statistical system. Mode of invasion (MI) and peritumoral lymphocytic infiltrating density (PLID) were significant and independent factors by multivariate analysis ( P =0.000, P =0.009 respectively), although univariate analysis showed that MI, PLID, T stage and Grading were significantly associated with nodal metastasis. A correlation exists only between T stage and MI by multivariate statistical test ( P = 0.045), while, PLID, T stage and Grading were significant parameters by univariate analysis. A highly dense PLI around cancer nest was observed which blocked nest from tissue and capillary lymph vessels.