通心络胶囊对老年2型糖尿病患者高脂血症的疗效观察

Clinical Observation on the Regulation Effect of Tongxinluo Capsule on Blood Fat in the Elderly of Type 2 Diabetes

目的:观察通心络对老年2型糖尿病患者血脂调节作用。方法:对符合诊断的130例高脂血症的2型糖尿病患者随机分两组,治疗组80例,服用通心络胶囊2粒,每日3次口服。阿托伐他汀10mg,每日1次睡前口服。对照组50例,单给予阿托伐他汀10?每日1次睡前口服。分别于治疗1个月后观察血脂的变化。结果:两组均有改善,治疗组显效48例,有效28例,总有效率95%。与对照组相比有统计学意义?P<0.01?。治疗组在胆固醇、甘油三酯、低密度脂蛋白及载脂蛋白B降低以及高密度脂蛋白及载脂蛋白A1升高等方面的变化与对照组有显著差异?P<0.05)。结论:通心络胶囊具有显著的降低胆固醇、甘油三酯、低密度脂蛋白、载脂蛋白B和升高高密度脂蛋白、载脂蛋白A1的作用,改善2型糖尿病患者的脂代谢紊乱且无毒副作用。

Objective ：To observe the regulation effect of Tongxinluo capsule on blood fat in the elderly of type 2 diabetes. Methods ：130 subjects with hyperlipemia of type 2 diabetes who were fit the diagnosis were randomly divided into two groups： study group （n = 80）and control group （n = 50）. Study group was given Tongxinluo capsule （2 pills, tid po）, lipitor（ 10 mg QN po） ,while control group was given lipitor（ 10 mg QN po）. The changes of blood fat lipid were respectively investigated after a month＇s. Result ：both boold fat changed significantly, marked improvements were founding in 48 cases and improvements in 28 cases in the study group,the effective rate being 95% ,showing significant differences （ P 〈 0.01 ）from control group. In the lowering of total cholesterin （ TC ）, toalglyceride （ TG）, Low - density lipoprotein （ LDL）, ApoB, and in the increasing of high - density lipoprotein（HDL）, ApoAl, there were also difference between the two groups with statistical significance （P 〈 0.05）. Conclusion ：Tongxinluo capsule can not only significantly reduce the levels of TC ,TG, LDL and ApoB but also increase the level of HDL, ApoAl ,Tongxinluo capsule could improve lipid metabolism disorder of type 2 diabetes and without marked side - effects.