前列腺癌组织中微血管密度测定及其意义

Microvessel density in prostatic cancer and its significance

应用ABC免疫组织化学技术对39例前列腺癌和10例前列腺增生症（BPH）组织中微血管密度进行检测。结果发现前列腺癌组织中微血管密度明显高于BPH（P＜0．001）；高分化前列腺癌组织中微血管密度明显低于低分化和未分化前列腺癌（P＜0．05和P＜0．01）；发生转移的前列腺癌中微血管密度明显高于未转移的前列腺癌。结果表明做血管密度与前列腺癌的发生及分化程度、浸润能力和自然病程密切相关。认为微血管密度在一定程度上反映了前列腺癌的恶性程度，并可作为判断前列腺癌生物学行为的一个有价值的指标。

Detection of microvessel density was carriced out in 39 cases of prostatic cancer and 10 cases of bening prostatic hyperplasia (BPH) using ABC irnmunohistochemical techniques. The result revealed that there was a significant difference of microvessel density between prostatic can-cer and BPH(P <0.001). Microvessel density in highly differentiated prostatic cancer was signifi-6antly lower than that in poorly and undifferentiated prostatic cancer (P<0.05 and P <0. 01 ). A significant difference in microvessel density between prostatic cancer with metastasis and without metastasis was noted (P <0.001). The result suggested that microvessel density might play a role in the carcinognesis of prostatic cancer and might serve as a useful marker for the assessment of the biological behavior of prostatic cancer.