摘要
大剂量地塞米松和ＳＯＤ是外伤性脑继发性损害药物治疗的新方案。本实验在豚鼠局灶性脑损伤模型上试用该两种药物，通过脑含水量、灶周伊文斯兰渗出、血ＣＫ、Ｃａ和ＬＤＨ含量测定以及光镜和电镜病理检查等指标，观察了它们的药效，结果与对照组比较，两药治疗脑继发性损伤均有一定的疗效，其中大剂量地塞米松效果较好，且有统计学意义。
Both high dose dexamethone and SOD are new drugs for treating traumatic brain secondary damage. We tried to use them in the model of regional brain injury in Guinea pigs. The drug effects were assessed by measuring the brain water content,Evans blue extravasation and blood CK, Ca and LDH values, and the histopathological findings under the light and electron microscopes. The results showed that the effects of high dose dexamethasone and SOD groups were more effective than that of control groups, and the high dose dexamethasone group got better effects than the SOD group as compared with control group, and had statistical significance.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1997年第4期239-241,共3页
Medical Journal of Chinese People's Liberation Army
关键词
脑损伤
药物疗法
病理学
地塞米松
brain injuries
drug therapy
pathology
dexamethasone
superoxide dismutase
