摘要
随着冠状动脉再通技术的发展,心肌缺血再灌注损伤的问题也越来越受到重视。过氧化物酶体增殖子激活受体(PPAR)-γ在大鼠心肌分布,而PPAR-γ激动剂除了具有胰岛素增敏作用外,还能抑制细胞炎症反应及细胞凋亡等发挥保护作用,本文就PPAR-γ激动剂对心肌缺血再灌注的保护作用的研究进展做一综述。
With the development of coronary artery recanalization technology, more and more attention are paid to myocardial ischemia-reperfusion injury. PPAR-γ is distributed in rat myocardium. Besides insulin sensitizing effect, the ligands of PPAR-γ can also exert its protective effects by inhibiting cell in- flammatory response and apoptosis. In this review, the author summarized the research advances of the protective effects of the ligands PPAR-γ on myocardial ischemia-reperfusion injury.
出处
《医学研究生学报》
CAS
2008年第4期416-419,共4页
Journal of Medical Postgraduates
基金
南京军区医药卫生科研基金资助项目(批准号:06MA126)