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过氧化物酶体增殖子激活受体-γ激动剂对心肌缺血再灌注损伤的保护作用的研究进展 被引量：6

Update of the protective effect of PPAR-γ ligand in myocardial ischemia-reperfusion injury
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摘要 随着冠状动脉再通技术的发展,心肌缺血再灌注损伤的问题也越来越受到重视。过氧化物酶体增殖子激活受体(PPAR)-γ在大鼠心肌分布,而PPAR-γ激动剂除了具有胰岛素增敏作用外,还能抑制细胞炎症反应及细胞凋亡等发挥保护作用,本文就PPAR-γ激动剂对心肌缺血再灌注的保护作用的研究进展做一综述。 With the development of coronary artery recanalization technology, more and more attention are paid to myocardial ischemia-reperfusion injury. PPAR-γ is distributed in rat myocardium. Besides insulin sensitizing effect, the ligands of PPAR-γ can also exert its protective effects by inhibiting cell in- flammatory response and apoptosis. In this review, the author summarized the research advances of the protective effects of the ligands PPAR-γ on myocardial ischemia-reperfusion injury.
作者 刘晓军 景华
机构地区 南方医科大学南京临床医学院(南京军区南京总医院)心胸外科
出处 《医学研究生学报》 CAS 2008年第4期416-419,共4页 Journal of Medical Postgraduates
基金 南京军区医药卫生科研基金资助项目(批准号:06MA126)
关键词 过氧化物酶体增殖子激活受体 缺血再灌注损伤 炎症反应 细胞凋亡 噻唑烷二酮类化合物 Peroxisome proliferators activated receptor Ischemia-reperfusion Inflammation Aoootosis Thiazolid dinedione
分类号 R364.1 [医药卫生—病理学]
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参考文献21

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二级参考文献21

  • 1林先和,李隆贵.过氧化物酶体增殖物激活受体γ基因转染对小鼠骨髓基质细胞向心肌细胞分化影响的研究[J].中华心血管病杂志,2004,32(7):622-625. 被引量：3
  • 2Shi-yingDING Zhu-fangSHEN Yue-tengCHEN Su-juanSUN QuanLiu Ming-zhiXIE.Pioglitazone can ameliorate insulin resistance in low-dose streptozotocin and high sucrose-fat diet induced obese rats[J].Acta Pharmacologica Sinica,2005,26(5):575-580. 被引量：5
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  • 8Wayman NS, Hattori Y,McDonald MC,et al. Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J, 2002, 16: 1027-1040.
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共引文献26

同被引文献124

引证文献6

二级引证文献31

医学研究生学报
2008年 第4期

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