噻唑啉环多头硫醚的合成及生物活性测试

Synthesis and biological activities of thiazoline multithioethers

通过5-甲基-2-噻唑烷硫酮与溴代物的亲核取代反应合成了四种甲基噻唑啉多头硫醚,利用红外光谱(IR)、核磁共振(1H NMR)光谱和元素分析对这四种化合物的结构进行了表征。采用PDA培养基平皿活性筛选法用22种真菌对合成的四种目标化合物进行了生物活性的初筛。测试结果显示:四种化合物均有生物活性,其中对水稻恶苗病菌都具有良好的杀菌作用。

4 kinds of methylthiazoline multithioethers were synthesized from the nucleophilic substitution of 5-methyl-thiazolidine-2-thione reacting with bromides, respectively. The target products were characterized by IR, IH NMR and elemental analysis. A bioactivity screening to 22 kinds of the common fungus by using PDA dish activity screening method was carried out. The result indicates that all target products exhibit bioaetivities,especially show antibacterial activities on fusarium moniliforme.