天然维生素E对药物代谢影响的研究进展

Study Advance of the Effect of RRR-a-tocopherol on the Drug Metabolism

最近研究表明天然维生素E能激活PXR受体,调控其下游靶基因CYP3A及MDR1的表达,而临床上50%的药物是通过CYP3A代谢,P-糖蛋白能转运大部分的抗生素,抗疟药,肿瘤化疗药物,CYP3A与P-糖蛋白底物及调控机制均相似,两者共同抵御外界化学物质进入细胞。在药物联合使用中天然维生素E很有可能影响其它药物代谢,产生药物相互作用。由P-糖蛋白或CYP3A代谢的药物与天然维生素E同时服用,可能会因为天然维生素E影响了CYP3A或P-糖蛋白的活性而产生药物相互作用,导致不良反应。

Recently study shows that vitamin E has functions far exceeding PHR and adjusting CYP3A and MDR1. In clinic, 50% medicine are metabolized by CYP3A. P-g protein can transport a large number of antibiotic, anti-aging, and anti-cancer drug. CYP3A and P-g protein can prevent outside chemistry matters from entering cell as their control system are the same. Take medicine which can metabolized by CYP3A and P-g protein with RRR-a-tocopherol can influence the metabolism of other drugs and produce dad reaction.