糖尿病与慢性溃疡致癌变的关系探讨

Relationship of diabetes mellitus,chronic ulcer and cancerization

目的探讨糖尿病与下肢慢性溃疡的关系及长期慢性溃疡与鳞状细胞癌的关系。方法用US-200尿液分析仪检测患者尿糖水平;用葡萄糖氧化酶法检测患者血糖;病理组织切片、SP免疫组化染色检查出患者下肢溃疡处为鳞状细胞癌。结果糖尿病患者伤口处难以愈合,反复长期慢性感染伤口可恶变为鳞状细胞癌。结论下肢肢端长期慢性溃烂伤口不愈合者应考虑糖尿病的存在;慢性溃疡长期不愈合而发生质地较硬之结节,边缘隆起,增长迅速,易出血,疼痛时应引起重视。

Objective To study the relationship of diabetes mellitus, chronic ulcer of lower extremity as well as correlation of long-term chronic ulcer and squamous cell carcinoma. Methods US-200 urine analyzer was applied to measuring the level of urine glucose; while glucose oxidase method measuring the level of blood glucose. Histopathologic slide and SP immunohistochemistry analysis showed that pathological change of chronic ulcer of lower extremity was squamous cell carcinoma. Results The wound was difficult to heal in patients with diabetes mellitus, and repeated, long-term and chronic infected wound was inclined to cancerate into squamous cell carcinoma. Conclusion Long-term and chronic lower extremity ulcer disunion is an indication of occurrence of diabetes mellitus. It can develop into hard nodus, with borderline caelate, growing rapidly, incline to bleeding and ache, should be paid more attention to.