局部晚期乳腺癌新辅助化疗疗效观察

The Observation of Effect of Neoadjuvant Chemotherapy on Locally Advanced Breast Cancer

目的比较3组不同化疗方案在局部晚期乳腺癌新辅助化疗中的疗效及毒副反应。方法90例Ⅱ、Ⅲ期乳腺癌随机分为2组,每组45例。A组应用CAF方案(环磷酰胺+吡柔比星+5-氟脲嘧啶),B组用TA方案(多西他赛+吡柔比星)新辅助化疗。完成2个周期新辅助化疗后评价疗效。结果A组总有效率为55.6%,B组的总有效率为82.3%,差异有统计学意义(P<0.05)。2组胃肠反应相似,A组发生率为84.4%,B组发生率为88.9%,差异无统计学意义(P>0.05)。B组骨髓抑制和脱发发生率分别为92.3%和84.4%,明显高于A组的73.3%和53.3%,差异有统计学意义(P<0.05)。结论2组新辅助化疗方案对乳腺癌治疗均有效,毒副反应均可耐受。TA组疗效及毒副反应均高于CAF组。

Objective To compare the efficacy and side effects the two different neoadjuvant chemotherapy regiments for the treatment of breast cancer. Methods 90 patients with stage Ⅱ, Ⅲ breast cancer were divided into two groups at random, and received CAF（ CTX, THP,5-Fu） ,TA （docetaxel,THP） regimen for neoadjuvant chemotherapy： The clinical therapeutic effect was valuated after 2 cycles of neoadjuvant chemotherapy. Results The overall response rates （RR） of group A and group B were 55.6% and 82.3% respectively, with significant statistical difference（P 〈 0.05 ）. The adverse reaction of gastrointestine was similar in group A （ 84.4% ） and group B （ 88.9% ） , there was no significant statistical difference（ P 〉 0.05 ）. But myelosuppression （ 92.3% ） and alopecia （ 84.4% ） in group B were greatly higher than those in group A （73.3 % and 53.3 % ） ,with significant statistical difference（ P 〈 0.05 ）. Conclusions The two different neoadjuvant chemotherapy regiments were both effective to the locally advanced breast cancer. Higher efficacy and more toxic reaction were observed in TA group than those in CAF group. The toxic reaction was tolerated.