芪冬活血饮对油酸致大鼠内皮素-1水平的影响

Effect of Qidong Huoxue Decoction on Rats’ ET-1 with Acute Lung Injury Caused by Oleic Acid

[目的]探讨急性肺损伤大鼠肺组织内皮素-1(ET-1)的变化及芪冬活血饮对其影响。[方法]SD大鼠随机分为空白对照组、模型组、中药组、地塞米松组及地塞米松加中药组,观察芪冬活血饮对大鼠油酸型急性肺损伤动物模型肺组织匀浆和肺泡灌洗液ET-1含量的影响。[结果]地塞米松加芪冬活血饮组ET-1含量最低,芪冬活血饮和地塞米松减少ET-1的作用相近,无统计学差异。[结论]芪冬活血饮减少ET-1的作用和地塞米松相近,并和地塞米松有明显的相加作用。

[Objective] To explore the change in rats＇ET-1 with acute lung injury and the effect of Qidong Huoxue Decoction on it. [Method] Randomly divide SD rats into blank control group, model group, TCM group, DXM group and DXM＋TCM group, observe the effect of Qidong Huoxue Decoction on animal model＇s lung tissue homogenate and pulmonary alveoli lavage solution ET- 1 with acute lung injury of rats oleic acid type. [Result] ET-1 was the lowest in DXM＋TCM group; Qidong Huoxue Decoction had similar function in reducing ET-1 with DXM, without statistical difference. [Conclusion] Qidong Huoxue Decoction and DXM have mutual reinforcing function.