鞘内注射纯氧治疗血管性痴呆的临床研究

INTRATHECAL INJECTION OF FILTRATED OXYGEN IN TREATING VASCULAR DEMENTIA

目的探讨鞘内注射过滤纯氧治疗血管性痴呆(VD)的临床疗效。方法将入选VD病人随机分为2组,治疗组26例,在应用扩血管药物等常规治疗的同时加用过滤纯氧鞘内注射治疗;对照组26例采用常规治疗。分别比较两组治疗后3月、6月后的MMSE评分、FAQ评分的变化情况及治疗6月后的疗效。结果治疗3月、6月后,治疗组MMSE评分分别为(18.76±4.27)和(20.48±4.76),均显著高于对照组(P<0.01);FAQ评分分别为(10.02±4.17)和(8.08±3.68),均显著低于对照组(P<0.01)。治疗6月后治疗组的总有效率为73.17%,对照组的总有效率为46.15%,两组比较有显著性差异(χ2=6.315,P<0.05)。结论应用鞘内注射纯氧治疗血管性痴呆,安全、方便,效果良好,值得推广应用。

Objective To explore the curative effect of intrathecal injection of filtrated oxygen on vascular dementia（VD）. Methods The VD patients were randomly divided into two groups. The 26 cases in the treatment group was given filtrated oxygen in addition to the routine therapy which was used in the contrast group. The curative effects after three month＇s and six month＇s treatments were evaluated according to MMse and FAQ. Results After 3 month and 6 - month treatments, the MMSE scores in the treatment group were （ 18.76 ± 4.27） and （20.48 ± 4.76）respectively, and both of which were much higher than those in the contrast group（ P 〈 0.01）. The FAQ scores were （10.02 ± 4.17） and 8.08 ± 3.68） respectively, both of which were much lower than those in the contrast group（ P 〈0.01, P 〈0.01）, The total curative effects of the treatment and contrast groups were 73.17 % and 46.15 % respectively after six- month treatment （x^2 = 6. 315, P 〈 0. 05）. Conclusion Intrathecal injection of filtrated oxygen can be used effectively and safely to treat vascular dementia.