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热休克蛋白的生物学功能及其对细胞的辐射防护作用 被引量：2

Biological Function of Heat Shock Proteins and Their Radiation Protection Function for Cells
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摘要 热休克蛋白(HSPs)是细胞在受到刺激后产生的非特异性保护蛋白,参与细胞的损伤修复。本文介绍了热休克蛋白的分类及其分子生物学特性,概述了其分子伴侣、抗细胞凋亡、抗氧化功能等细胞保护作用的机制,从射线诱导HSPs表达、抗辐射诱导的细胞凋亡、DNA损伤防护等方面总结了HSPs的辐射防护作用。HSPs有可能成为新一代辐射损伤防护剂。 Heat shock proteins （HSPs） are nonspecific protective proteins produced by ceils after receiving stress stimulation which participate in cell damage repair. This article introduced classification of heat shock proteins and their molecular biological features, and outlined the mechanisnts of their protective functions for cells, such as molecular chaperones, antiapoptosis and antioxidation. This article also summarized radiation protective functions of heat shock proteins from following aspects： rays induce the expression of heat shock proteins, resisting cell aopoptosis induced by radiation and DNA damage protection. Heat shock proteins have the potential of being a new generation protective agent against radiation damage.
作者 李义杰 张保国
机构地区 苏州大学放射医学与公共卫生学院
出处 《辐射防护通讯》 2007年第6期31-36,共6页 Radiation Protection Bulletin
关键词 热休克蛋白 细胞保护 辐射防护 应激 Heat shock proteins Cell protection Radiation protection Stress stimulation
分类号 R852.7 [医药卫生—航空、航天与航海医学]
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参考文献31

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二级参考文献40

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辐射防护通讯
2007年 第6期

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