酸相关性胃病患者胃酸pH值与生活事件的关系

Life Events and Gastric Acid pH Value of Patients with Acid-Related Diseases

目的:探讨酸相关性胃病患者胃酸pH与生活事件量表(life event scale,LES)评分的相关性,比较不同胃酸pH组受试LES因子分的差异。方法:对酸相关性胃病患者行LES评定,按胃酸pH值的簇集性分三组共108例,第一组胃酸在pH1.3(n=37),第二组胃酸pH1.6～1.7(n=32),第三组胃酸pH2.1～4.5(n=39)。结果:胃酸pH值越低,生活事件总刺激量和LES各因子分越高,如总分三组分别为40.0±20.6,15.1±9.2及6.4±6.5,依次相差一倍以上(F=43.26,P<0.01)。家庭因子、工作学习及社交因子也存在同样的变化(20.5±13.3/5.3±5.1/2.9±5.0,7.7±9.1/6.0±6.4/2.5±4.8,11.8±11.5/3.8±4.9/0.9±2.7,F=29.31、6.07、13.34,均P<0.01),相关分析显示胃酸pH与LES条目中的受到惊吓或经历灾难(f48)及本人重病或重伤(f27)的得分负相关(r=-0.34、-0.30,P<0.01)。结论:高生活事件与酸相关性胃病患者胃酸分泌增多相关。

Objective： To investigate the correlation between gastric acid pH value of patients with acid-related gastric diseases and the score of their life events. Methods： To evaluate the LES （ life event scale） of the 108 patients with acid-related diseases were divided into 3 groups according their chester of gastric acid pH value, group one pH 1.3 （n=37）, group twopH 1.6-1.7 （n=32）, group threepH2.1-4.5 （n=39） . Results： TheLES total score and factor scores increased with the gastric acid level, the total score of the three groups were 40. 0 ± 20. 6, 15. 1 ± 9. 2, 6.4 ± 6. 5 respectively, the differences among the three groups were significant （ F = 43.26, P 〈 0.01 ） . The three factor scores of family affair, work or study and social were also higher in group with high acid level （ 20. 5 ± 13.3/5.3±5.1/2.9±5.0, 7.7±9.1/6.0±6.4/2.5±4.8, 11.8±11.5/3.8±4.9/0.9±2.7, F=29.31,6.07, 13.34 respectively, P 〈0. 01 ） . The Pearson correlate analysis suggested there were significant negative correlation between gastric acid pH values and two item scores of LES （ frightened or experienced disaster; heavely ill or injured, r = -0. 30, -0. 34, P 〈0. 01 ） . Conclusion： high frequency of life event is asssoeiated with more gastric acid secretion of patients with acid-related diseases.