111例慢性肝病医院感染临床分析

Hospital infection in 111 patients with chronic liver diseases

目的分析调查慢性肝病医院内感染的原因并探讨预防措施。方法对慢性肝病合并医院内感染111例的临床资料进行回顾性调查并进行临床分析。结果慢性肝病院内感染率为19．8％，慢性重型肝炎居首位，其次是肝癌，失代偿期肝硬化居第三，慢性肝炎居第四，经统计学检验差异有统计学意义。提示肝功能损害越重，医院感染发生率越高。呼吸系统感染最常见，其次是腹腔感染，胃肠道第三。病原学革兰氏阴性杆菌和阳性球菌为主，真菌也占相当比例。合并医院感染的病死率高于非医院感染者。结论有效防治医院感染对于提高慢性肝病的疗效有极其重要的作用。

Objective To investigate the reasons of hospital infection in patients with chronic liver diseases and probe into the preventive measures. Methods Clinical data of 111 hospital infection patients with chronic liver diseases Were analyzed by retrospective analysis. Results The rate of hospital infection with chronic liver diseases was 19.8%. The first was chronic severe hepatitis;second was hepatocarcinoma; the next was decompensated cirrhosis and chronic hepatitis was last. All of the above results were significant in statistics. It suggested that the higher hospital infection rate associated with degree of liver function damage. Respiratory tract infection was the highest and abdominal infection was the secondary;the third was gastrointestinal tract. The dominant pathogens were Gram - negative bacterium and Gram - positive cocci. Moreover, fungi had a considerable proportion. The mortality rate combined with hospital infection was higher than the non - infections. Conclusion The prevention and treatment of hospital infection have important meanings for the improvement of prognosis and increasing therapeutic effect on chronic liver diseases.