阿比朵尔胶囊在健康人体内的药动学(英文)

Pharmacokinetics of arbidol capsule in Chinese healthy volunteers

目的研究阿比朵尔胶囊在健康人体内的药动学。方法20名健康志愿者单剂量口服阿比朵尔胶囊200 mg后,血浆样品经液-液萃取后,以液相色谱紫外检测法测定血药浓度。用3P87统计软件进行数据处理。结果结果符合一级消除药动学的二室模型,阿比朵尔胶囊的主要药动学参数分别为:c_(max)一(418±s 241)μg·L^(-1),t_(max)(1.3±1.2)h,t_(1/2α)(1.9±2.3)h,t_(1/2β)(14±5)h,AUC_(0～t)(2633±1071)μg·h·L^(-1),Vc/F(0.7±0.6)L,CL(0.08±0.03)L·h^(-1)。结论阿比朵尔胶囊在人体内药动学过程符合二室开放模型,本试验可为临床用药提供药动学参数。

AIM To study the pharmacokinetics of arbidol capsule in Chinese healthy volunteers. METHODS A single oral dose of arbidol capsule 200 mg was given to 20 healthy volunteers respectively. Plasma samples were prepared based on a simple liquid-liquid extraction. The extracted samples were analyzed by HPLC equipped with UV detection. Pharmacokinetic parameters were calculated by 3P87 software. RESULTS The main pharmacokinetic parameters of arbidol were as follows： Cmax （418 ± S 241 ）μg· L^-1, tmax （1.3 ± 1.2） h, t1/aα （1.9 ± 2.3） h, t1/2 β（14 ± 5） h, AUC0-t （2 633 ± 1 071） μg·h·L^-1, Vc/F （0.7 ± 0.6） L, CL （0.08 ± 0.03） L· h^-1. CONCLUSION The pharmacokinetics of arbidol capsule in human body accord with two-compartment open model. The study will offer the pharmacokinetic parameters for the clinical application of arbidol.