Survivin在胃肠道间质瘤中的表达及其与VEGF表达的相关性

Expression of Survivin in gastrointestinal stromal tumors and its correlation with VEGF

目的探讨凋亡抑制蛋白Survivin在胃肠道间质瘤(GISTs)组织中的表达情况及其与VEGF表达的相关性。方法采用免疫组化S-P法检测57例胃肠道间质瘤组织中Survivin蛋白和VEGF蛋白的表达情况。结果57例GISTs中,Survivin阳性率为66.7%,VEGF阳性率为73.7%。Survivin和VEGF蛋白的阳性表达与GISTs的恶性潜能相关(P<0.01,P<0.05),两者的表达均与GISTs浸润转移、肿瘤直径及坏死相关(P<0.01,P<0.05),而与年龄、性别及发病部位无关(P>0.05)。Survivin表达与VEGF表达成正相关(P<0.05)。结论Survivin、VEGF可作为反映GISTs生物学特性的标志物,检测Survivin、VEGF的表达有助于GISTs恶性潜能的评估。Survivin与GISTs组织中VEGF的表达成正相关,两者可能协同促进GISTs的血管生成,参与GISTs的发生发展。

Objective To investigate the expression of inhibitor of apoptosis protein, Survivin, in gastrointestinal stromal tumorS（GISTs） and analyze its correlation with the expression of VEGF. Methods The expressions of Survivin and VEGF were examined by using the streptavidin-biotin peroxidase（SP） method in 57 cases of GISTs. Results Survivin was expressed in 38 of 57 （66.7%） cases of GISTs and VEGF was expressed in 42 of 57 （73.7%） cases of GISTs. The positive rates of Survivin and VEGF were associated with the malignant potential of GISTs（P 〈 0.01 ,P 〈 0.05） , and also associated with infiltration and metabasis, tumor diameter and necrosis of GISTs（P 〈 0.01, P 〈 0.05 ） , but had nothing to do with patients＇ age, sex and initial occurring position （P 〉 0.05）. Survivin expression was positively related to VEGF expression（P 〈 0.05）. Conclusions Survivin and VEGF can be valuable indicators of the biological characteristics of GISTs. The detection of Survivin and VEGF is available to the evaluation of the malignant potential of GISTs. A positive correlation between expressions of Survivin and VEGF is observed in GISTs. They are probably involved in the pathogenesis of GISTs by promoting angiogenesis cooperatively.