大肠癌组织中EPO-R的表达意义及与MVD的关系

Significance of erythropoietin receptor expression and microvessel density in colorectal carcinoma

目的:探讨大肠癌组织中EPO-R的表达及其与MVD在血管生成、侵袭和转移中的作用及其相关性。方法:应用免疫组化方法检测48例大肠癌组织及正常大肠组织中EPO-R的表达,并对血管进行CD34相关抗原的免疫组化染色,计数MVD。分析EPO-R与微血管密度(MVD)的关系。结果:EPO-R在大肠癌中的表达率高于癌旁及正常大肠组织,差别有显著统计学意义(P<0.01),且EPO-R表达及MVD值与肿瘤分化、Dukes分期、淋巴结转移有显著相关性(P<0.05)。EPO-R表达阳性组织中,MVD计数显著高于EPO-R表达阴性者(P<0.05)。结论:结直肠癌组织中存在EPO-R表达且过表达率高,而癌旁结肠组织几乎不表达,可为临床诊断提供依据。EPO-R表达与MVD值紧密相关。血管生成增加,从而影响肿瘤的浸润和转移等生物学行为。

Objective：To explore the expression of erythropoietin receptor in colorectal carcinoma; and the relation with microvessel density （MVD） in human colorectal carcinoma. Methods：The expression of EPO -R in surgical samples of 48 cases carcinoma and nomal colorectal tissue were investigated by immunohistochmcal method. Resuits：The expression level of EPO - R in colorectal carcinoma tissue was higher than normal colorectal tissue. And it was significantly associated with differentiation, Dukes stage and lymph nodes metastasis （ P 〈 0.05 ）. The MVD in EPO - R positive patients was significantly hight than that in EPO - R - negative patients （P 〈 0.05 ）. Conclusion： EPO - R was expressed in colorectal carcinoma, the ratio of over - expressed is high. The expression of EPO - R has a closely relationship with angiogenesis in colorectal carcinoma. It act as an angiogenic growth factor which can affect the biological behavior of tumors.