p63、Bak基因蛋白在宫颈鳞癌中的表达及意义

Expression and significance of p63 and Bak in cervical squamous cell carcinomas

目的:探讨宫颈鳞状细胞癌中凋亡凋控因子p63和Bak蛋白的表达及其意义。方法:采用免疫组织化学技术检测40例宫颈鳞状细胞癌及10例正常宫颈组织中p63和Bak蛋白的表达水平。结果:p63蛋白在宫颈鳞状细胞癌中表达水平高于正常宫颈组织(P<0.05)。Bak蛋白在宫颈鳞状细胞癌中表达水平低于正常宫颈组织(P<0.05)。p63及Bak蛋白的表达水平在不同分化程度的宫颈癌之间的差异有显著意义(P<0.05)。结论:宫颈鳞状细胞癌的发生、发展与p63及Bak蛋白的异常表达有关,可能是细胞异常增殖和凋亡失衡的结果。

Objective： To investigate the expression and significance of p63 and Bak in cervical squamous cell carcinomas. Methods： Immunohistochemical technique was used to detect the expression of p63 and bak in 40 cases of cervical squamous cell carcinomas, 10 normal cervical tissues. Results ： Expression of p63 were observed in cervical carcinomas, that was higher in cervical carcinomas than in normal cervical tissues （ P 〈 0.05 ）, and bak was lower in cervical carcinomas than in normal cervical tissues （ P 〈 0.05 ）. Significant differences were observed for p63 and bak expression levels in different differentiated cervical carcinoma（P 〈0.05 ） . Conclusion： The abnormal expression of p63 and Bak may be a positive factor in the pathogenesis of cervical squamous cell carcinomas . The results suggest that cervical squamous cell carcinomas may result from abnormal preliferation and unbalanced apoptosis.