维生素B_(12)混合液治疗宫颈癌患者急性放射性皮肤损伤的疗效观察

Observation of the curative effect on cervix cancer patients with radio therapy skin destruction by Vitamin B_(12) mixed liquor

目的:探讨宫颈癌放疗患者急性放射性皮肤损伤的防治方法。方法:对2005年8月-2006年10月我院98例宫颈癌放疗患者出现I级放射性皮肤损伤时即进行配对分组治疗,实验组用维生素B12混合液(VitB12500μg×20支+0.9%生理盐水250ml+庆大霉素48万U+地塞米松20mg)纱布浸湿局部外敷,15-20分钟/次,2-3次/日,7天为1疗程,连用4个疗程;对照组单用金因肽液喷涂,疗程同上。结果:实验组:总治愈率18.37%(9/49);总有效率(CR+PR)69.39%(34/49);其中腹股沟区、会阴部和肛门周围总有效率(CR+PR)65.91%(29/44);对照组:总治愈率8.16%(4/49);总有效率(CR+PR)42.86%(21/49);其中腹股沟区、会阴部和肛门周围总有效率(CR+PR)41.30%(19/46)。总治愈率两组无显著性差异;总有效率两组有显著性差异,P<0.05;腹股沟区、会阴部和肛门周围总有效率两组有显著性差异。结论:宫颈癌放疗患者急性放射性皮肤损伤关键在于早期预防和治疗,维生素B12混合液湿敷是治疗急性放射性皮肤损伤的一种既经济又有效的方法。

Objective： To study the prevention and therapy for patients with cervix cancer and radioactiviticy skin destruction Methods： Ninety- eight cervix cancer patientswith grade 1 skin destruction after radio therapy entered the study. The experiment group used vitamin B12mixed liquor（ Vitamin B12 500μg × 20Amp and 0.9% NS 250ml and gentamicin 48U and hexadecadrol 20mg） and applied the part with sodden gauze, 15 -20minute ,2 -3 times per day. A course of treatment was seven days, totally 4 courses; the control group only used genetime spray painting, and the courses were the same as experiment group. Results： The experiment group： total cure ratel8.37% （9/49） ; total effective rate（CR ＋ PR）69.39% （34/49） ; total effective rate of iliac region, perineal position and anus surrounding （CR ＋ PR）65.91% （29/44） ;the control group： total cure rate（ CR/N ） 8.16% （4/49） ;total effective rate （CR ＋ PR）41.30% （19/46）. total effective rates of, the two group had obvious differences; for total effective rates of Iliac region, perineal position and anus surrounding had obvious difference. Conclusion： B12 mixed liquor, is an economic and effective method for acute radiotherapy skin destruction.