肿瘤患者医院真菌感染及耐药性监测

Analysis of distribution of nosocomial fungal infection in tumor patients and their antibiotic resistance

目的:了解肿瘤患者医院真菌感染及耐药状况,为合理选用抗真菌药提供依据。方法:对我院送检的863例患者标本培养及药敏试验结果进行分析。结果:863例患者共检出真菌121株(占14.02%)。其中以白色念珠菌最为常见,占69.4%(84/121)。药敏结果显示:本组真菌对益康唑(ECO)、酮康唑(KET)的耐药率较高,分别为34.7%和29.0%,而对咪康唑(MIC)、两性霉素B(AMB)、制霉菌素(NYS)和5-氟胞嘧啶(5-FC)的耐药率分别为20.0%、3.3%、1.65%和1.65%。结论:肿瘤患者并发真菌感染以白色念珠菌为主。应根据药敏结果合理用药。

Objective：To investigate the fungal pathogens and drug resistance in tumor patients with fungal infection. Methods： A total of 863 patients data were collected from tumor patients with fungal infection. Their resistance to antifungal agents were analyzead. Results：The incidence of fungal infection was 14.02% （121/863）among all the samples . Candida albicans was the major fungus and accounted for 69.4% （84/121）. Resistance rates of fungus against econazole （ECO） and ketoconazole （KET）were 34.7% and 29.0% , resitstance rates to miconazole（MIC） , amphotericin B（AMB） ,nystain （NYS） and 5 - flucytosine（5 - FC） were 20.0% ,3.3% ,1.65% and 1.65%. Conclusion： The main pathogens causing fungal infection in tumor patients is candida albicans. The results of antifungal susceptibility test can guide the clinical antifungal therapy.