FAK-原发性肝癌分子靶向治疗的新希望

FAK-New hope for molecular targeted therapies in primary hepatic carcinoma

粘着斑激酶(focal adhesion kinase,FAK)是位于胞浆的一种非受体型酪氨酸激酶,它的功能包括调节细胞生长发育、存活和凋亡,以及调节细胞与细胞外基质黏附、细胞骨架重组等。FAK的高表达与多种肿瘤的发生发展、侵袭和转移有关。与正常肝组织和肝硬化组织相比,FAK的mRNA及蛋白水平在肝癌组织中呈过度表达或过度激活状态。FAK与肝癌细胞的增殖、凋亡、黏附、侵袭和转移密切相关,可望成为原发性肝癌分子靶向治疗的一个新希望。

Focal adhesion kinase （FAK） is cytoplasmic non-receptor type protein tyrosine kinase, the functions of FAK include regulating the growth and development, survival, apoptosis of cells, as well as regulating cell adhesion to extracellular matrix, recombination of cytoskeleton. Overexpression of FAK is concerned with the develop- ment, invasion, metastasis of many tumors. In contrast to normal liver and liver cirrhosis tissues, FAK mRNA and protein levels are overexpressed or overactived in liver cancer tissues. FAK is implicated in proliferation, apoptosis, adhesion, invasion, metastasis of hepatoma carcinoma ceils, it is conceivable that it would be another new hope for targeted therapies in primary hepatic carcinoma.