抑癌基因PTEN与食管癌关系研究进展

The relationgship of suppressor gene PTEN and esophageal carcinoma

目的:PTEN是近年发现的一种与细胞信号传导途径有关的具有双特异性磷酸酶活性的新型抑癌基因,了解抑癌基因PTEN在食管癌(EC)中的最新研究进展在指导食管癌的治疗上可能具重要意义。方法:检索并分析近10年国内外有关PTEN与EC研究的文献。结果:在EC组织中,PTEN基因突变发生频率比较低,但PTEN蛋白表达下调却很普遍,表达程度与食管癌的恶性程度及预后密切相关。结论:抑癌基因PTEN低表达可能参与了EC的发生发展及肿瘤性血管的形成。

Objective： PTEN is a tumor suppressor gene which was identified in recent years. It encodes a dual specific protein - phospholipic phosphatase involved in a variety of signal transduction pathways. To investigate the new progresses in tumor suppressor gene PTEN and esophageal carcinoma（EC） will do a great help to the therapy of esophageal carcinoma. Methods： The international reseach literatures about PTEN and EC in recent 10 years were reviewed. Results： The PTEN gene mutations in EC were not often founded,but the reduction of the expression of the PTEN protein was commonly detected , and the expression of PTEN protein was closely related with the degree of the differentiation of carcinoma and the prognosis of tumors. Conclusion： The decreased expression of PTEN may play an important role in the development, progression and tumor angiogenesis of esophageal carcinoma.