摘要
C-型钠尿肽(C-type natriuretic peptide,CNP)作为钠尿肽家系的一员,主要是由血管内皮分泌,CNP与血管平滑肌细胞钠尿肽受体-B(NPR-B)结合,激活颗粒型鸟苷酸环化酶,促进细胞内cGMP水平升高,以旁分泌和/或自分泌方式调节循环系统功能稳态。CNP广泛分布于血管系统,尤其在内皮细胞中高表达。CNP具有利钠、利尿、调节血管张力、抑制血管平滑肌细胞迁移、增殖等作用,与高血压、动脉粥样硬化、血栓形成、冠脉成形术后再狭窄和血管钙化等多种血管损伤性疾病密切相关。
C-type natriuretic peptide （CNP） is a member of Natriuretic peptides family which is synthesized and secreted by vascular endothelial ceils. CNP can bind with specific G-protein coupling receptor - natriuretic peptide receptor-B （NPR-B） and elevate cellular cGMP level by activating guanylate cyclase. CNP regulates homeostasis of circulating system in an autocrine/paracrine manner. Vascular system, especially endothelium, is rich in CNP and its receptor. CNP exerts natruretic and natriuretic effect and regulates vessel tone, inhibits migration and proliferation of vascular smooth muscle cell. CNP is tightly correlated with injured vascular diseases such as hypertension, atherosclerosis, thrombogenesis, restenosis and vascular calcification.
出处
《生理科学进展》
CAS
CSCD
北大核心
2008年第2期119-123,共5页
Progress in Physiological Sciences
基金
教育部新世纪优秀人才基金(NCET-05-0016)
国家自然科学基金(30470693,30570766)资助课题
关键词
钠尿肽
血管损伤性疾病
血管钙化
natriuretic peptide
injured vascular disease
vascular calcification
