细胞骨架与胰岛素相关信号转导通路

Cytoskeleton and Insulin Related Signal Transduction Pathways

细胞骨架是蛋白质纤维交织形成的立体网架体系,它是一个动态结构,可随着生理条件的改变不断进行组装和去组装,并受到细胞内外因素的调节。胰岛素是参与机体内诸多生理过程如葡萄糖转运、基因表达和DNA合成等的重要激素,而胰岛素的正常分泌是其功能发挥的重要前提。越来越多的研究表明,细胞骨架在胰岛素行使功能和胰岛素的分泌过程中起重要作用,其具体机制与胰岛素相关的信号转导通路密切相关。当细胞骨架成分发生改变,继而影响到胰岛素相关的信号转导过程时,就会影响胰岛素的分泌,同时会导致胰岛素抵抗的发生。

Cytoskeleton is a stereo wire frame system of filament, which is in a dynamic state. It can assemble or disassemble continuously with the change of physiological condition, and be regulated by many factors interior and exterior of the cell. Insulin is an important hormone involving in lots of physiological functions such as transport of glucose, gene expression and DNA synthesis. Normal secretion of insulin is the significant premise for which to educe its functions. Many studies indicate that cytoskeleton plays an important role in the process of insulin action and secretion, with a mechanism referring to insulin related signal transduction pathways tightly. The change of cytoskeleton influencing insulin related signal transduction pathways will lead to incidence of insulin resistance.