期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CDK2在精母细胞和卵母细胞减数分裂中的作用 被引量：1

下载PDF
导出
摘要 细胞周期蛋白依赖性蛋白激酶(Cyclin-dependent kinase,CDK)2是驱动细胞通过G1/S期检验点进入S期完成DNA合成的关键性调控蛋白。过去一度认为CDK2在减数分裂中的作用不像在有丝分裂中那么重要。直至2003年在敲除小鼠CDK2基因后出乎意料地发现小鼠生长发育正常,只是不育:生殖细胞减数分裂受到影响。这一发现引起人们重新审视CDK2在细胞增殖中的作用,对CDK2在减数分裂中的作用研究受到关注,本文就此作一综述。
作者 关泽红 旭日干
机构地区 内蒙古大学哺乳动物生殖生物学与生物技术教育部重点实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2008年第2期169-171,共3页 Progress in Physiological Sciences
基金 国家“863”计划(2002AA242061) 国家自然科学基金(3060009)资助课题
关键词 CDK2 减数分裂 配子发生
分类号 Q253 [生物学—细胞生物学] R329.2 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献10

  • 1de Carcer G, de Castro IP, Malumbres M. Targeting cell cycle kinases for cancer therapy. Curr Med Chem, 2007, 14 : 969- 985.
  • 2Berthet C, Aleem E, Coppola V, et al. Cdk2 knockout mice are viable. Curr Biol, 2003,13 : 1775- 1785.
  • 3Kierszenbaum AL. Cell-cycle regulation and mammalian gametogenesis: a lesson from the unexpected. Mol Reprod Dev, 2006,73 : 939 -942.
  • 4Furuno N, Ogawa Y, Iwashita J, et al. Meiotic cell cycle in Xenopus oocytes is independent of cdk2 kinase. EMBO J, 1997,16 : 3860-3865.
  • 5Berthet C, Kaldis P. Cell-specific responses to loss of cyclin-dependent kinases. Oncogene. 2007 , 26 : 4469 - 4477.
  • 6Liu J, Grimison B, Lewellyn L, et al. The Anaphase-promoting Complex/Cyclosome inhibitor Emi2 is essential for meiotic but not mitotic cell cycles. J Biol Chem, 2006, 281 : 34736-34741.
  • 7Grimison B, Liu J, Lewellyn AL, et al. Metaphase arrest by cyclin E-Cdk2 requires the spindle-checkpoint kinase Mps1. Curr Biol, 2006 ,16 : 1968 - 1973.
  • 8Liu J, Grimison B, Maller JL. New insight into metaphase arrest by cytostatic factor: from establishment to release. Oncogene, 2007 , 26 : 1256-1259.
  • 9Ravnik SE, Wolgemuth DJ. Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. Dev Biol, 1999, 207 : 408 -418.
  • 10Ashley T, Walpita D, de Rooij DG. Localization of two mammalian cyclin dependent kinases during mammalian meiosis. J Cell Sci, 2001,114 : 685-693.

同被引文献36

  • 1李丹,卢光琇.细胞周期调控基因在精子发生中的作用[J].国外医学（遗传学分册）,2005,28(1):25-28. 被引量：4
  • 2唐爱发,余振东,桂耀庭,郭新,张立兵,张键荣,刘春霖,蔡志明.睾丸特异性基因TSF22在小鼠中的表达研究[J].中国男科学杂志,2007,21(2):11-15. 被引量：3
  • 3Van der Krift TP, Leunissen J, Teerlink T, et al. Ult rastruc- tural localization of a peroxi somal protein in rat liver using the specific antibody against the non-specif ic lipid transfer protein ( sterol carrier protein 2 ) [ J ]. Biochim Biophys Acta, 1985, 81-2(2) :387-392.
  • 4Seo EK, Kim TW, Park HH. Expression, crystallization and preliminary X-ray crystallographic studies of SCP3 coiled-coil do- main[J]. Acta Cryst, 2013,69 (Pt11):1281-1283.
  • 5Arango NA, Li L, Dabir D, et al. Meiosis I Arrest Abnormali- ties Lead to Severe Oligozoospermia in Meiosi I Arresting Pro- tein ( Mlap )-Deficient Mice [ J]. Biol Reprod, 2013,88 (3) :76.
  • 6Roeder GS. Meiotic chromosomes: it takes two to tango [ J ]. Genes Dev,1997, 11:2600-2621.
  • 7Yang F, Gell K, van dr Heijden GW, et al. Meiotic failure in male mice lacking an X-linked factor [ J ]. Genes Dev, 2008,22 ( 5 ) :682-691.
  • 8La Salle S, Palmer K, O' Brien M. Spata22, a novel Verte- brute-Specific gene, Is required for meiotic progress in mouse germ cells[J]. Biol Reprod, 2012,86(2) :45.
  • 9Ishishita S, Inui T, Matsuda Y, et al. Infertility associated with meiotic failure in the tremor rat (tin/tin) is caused by the deletion of spermatagenesis associated 22 [ J ]. Exp Anita, 2013,62(3 ) :219-227.
  • 10Nasmyth K, Haering CH. The structure and function of SMC and kleisin complexes [ J ]. Annu Rev Biochem, 2005,74 : 595 -648.

引证文献1

二级引证文献1

生理科学进展
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部