益肾生血饮治疗肾性贫血的研究

Study of Yishenshengxueyin on renal anemia

目的观察益肾生血饮治疗慢性肾衰竭所致肾性贫血的效果,并进一步探讨和认识可能的作用机制。方法将62例脾肾阳虚型肾衰竭期肾性贫血患者分为治疗组32例和对照组30例。在基础治疗的同时治疗组服用益肾生血饮,疗程为2个月。观察治疗前后血肌酐(SCr)、内生肌酐清除率(Ccr)、血红蛋白(Hb)、红细胞压积(HCT)、铁蛋白(SF)、转铁饱和度(TS)以及静息状态下收缩压(SBP)与舒张压(DBP)的变化。结果治疗组总有效率88%,显著优于对照组60%(P<0.01);同时能减少SCr、BUN,与对照组比较有显著性差异(P<0.05);提高Hb、HCT与对照组比较有显著性差异(P<0.05);在改善中医症状方面显示了较好疗效,且对血压无明显影响。结论益肾生血饮能够节省红细胞生成素药物剂量、明显改善肾性贫血,减少红细胞生成素升高血压的不良反应,改善中医症状,保护残存肾功能,延缓肾衰恶化。

Objective It is to observe the efficacy of Yishenshengxueyin on renal anemia induced by chronic renal failure, and then deeply to discuss and know the possible action mechanism. Methods 62 patients with renal anemia in renal failure stage with asthenia of both spleen and kidney were divided into treatment group in which there was 32 cases and control group in which there was 30 cases. Based on elementary therapy, treatment group was treated with Yishenshengxueyin. The course of treatment was two months. The changes of serum creatinine （SCr）, creatinine clearance rate （Ccr）, hemoglobin （Hb）, hematoerit （HCT）, serum ferritin （SF）, transferring saturation （TS）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） before and after treatment were observed. Results The total effective rates of treatment group （88 % ） outstripped significantly that of control group （60 % , P〈 0.01）. SCr and BUN in treatment group were decreased and there was significant difference compared with control group （P〈 0.05）. Hb and HCT in treatment group were heightened and there was significant difference compared with control group （P〈 0.05）. In treatment group, improving traditional Chinese medical symptoms showed good efficacy and there was no obvious influence on blood pressure. Conclusion Yishenshengxueyin can save the drug dose of EPO, improve obviously renal anemia, decrease the untoward reaction of EPO heightening blood pressure, improve traditional Chinese medical symptoms, protect the relic renal function and delay the exacerbation of renal failure.