摘要
目的探讨肝、肾移植受者环孢素A(CsA)理想的血药浓度监测指标。方法采用荧光偏振免疫法,对65例肝移植受者及136例肾移植受者进行CsA谷浓度(C0)及服药后2 h血药浓度(C2)监测,并对数据进行归纳和分析。结果肝移植受者C2/C0均值为3.56,肾移植受者C2/C0均值为4.8,肝、肾移植受者C2/C0均值有极显著差异(P<0.001);肝移植受者男性CsA血药浓度较女性低。结论C0+C2和C2/C0作为CsA血药浓度监测指标,能更全面地反映CsA体内药物暴露情况和监测CsA肝、肾毒性。
：Purpose To discuss an ideal index of monitoring whole blood concentration of cyclosporine A （CsA） in the patients after a liver or kidney transplantation. Methods The trough concentration （C0） and the peak concentration（ C2） of CsA were determined by Fluorescence polarization immunoassay （FPIA） method in 42 cases of liver transplantation and 136 cases of kidney transplantation. Results The mean value of ratio of Co and C2 （C0/C2） in liver transplant recipients and kidney transplant recipients is 3.6 and 4.8 respectively. The mean value of C0/C2 in liver or kidney transplant recipients with different gender was different obviously. Conclusion The value of C0 ＋ C2 and C0/C2 can be an ideal and safe index to reflect the metabolism process of CsA in liver or kidney transplant recipients, especially C0/C2.
出处
《中国生化药物杂志》
CAS
CSCD
2008年第2期110-112,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
肝移植
肾移植
环孢素A
血药浓度
荧光偏振免疫法
liver transplantation
kidcncy transplantation
cyclosporinc A
blood drug concentration
fluorescence polarization immunoassay
