期刊文献+

脑脊液置换并尼莫地平静脉滴注治疗蛛网膜下腔出血疗效观察

下载PDF
导出
摘要 目的:探讨脑脊液置换并尼莫地平静脉注射治疗蛛网膜下腔出血(SAH)后脑血管痉挛(CVS),降低再出血及病死率。方法:将SAH患者120例随机分为脑脊液置换组(60例)和常规治疗组(60例),常规组予脱水、止血及尼莫地平口服等常规治疗,脑脊液置换组在脱水、止血基础上行脑脊液置换并尼莫地平静脉滴注。结果:两组患者在缓解剧烈头痛、缩短患者头痛及颈项强直持续时间,降低CVS发生率、再出血率及病死率方面差异有显著性,脑脊液置换组明显优于常规组。结论:脑脊液置换并尼莫地平静脉滴注治疗SAH具有较好的临床疗效,值得推广。
作者 石香彩
出处 《医学理论与实践》 2008年第4期421-422,共2页 The Journal of Medical Theory and Practice
  • 相关文献

参考文献3

二级参考文献25

  • 1[6]Besselmann M,Vennemann B,Lowens S,et al.Internal carotid artery dissection[J].Neurology,2000,54(2):442
  • 2Bertsch T,Kuehl S,Muehlhauser F,et al.Source of endothelin-1 in subarachnoid hemorrhage.Clin Chem Lab Med,2001,39(4):341-345.
  • 3Nishizawa S,Chen D,Yokoyama T,et al.Endothelin-1 initiates the development of vasospasm after subarachnoid haemorrhage through protein kinase C activation,but does not contribute to prolonged vasospasm.Acta Neurochir (Wien),2000,142(12):1409-1415.
  • 4Zubkov AY,Rollins KS,Parent AD,et al.Mechanism of endothelin-1-induced contraction in rabbit basilar artery.Stroke,2000,31 (2):526-33.
  • 5Beg SA,Hansen-Schwartz JA,Vikman PJ,et al.ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET (B) and 5-HT (1 B) receptor upregulation after subarachnoid hemorrhage in rat.J Cereb Blood Flow Metab,2005,32(5):411-417.
  • 6Lan C,Das D,Wloskowicz A,et al.Endothelin-1 modulates hemoglobin-mediated signaling in cerebrovascular smooth muscle via RhoA/Rho kinase and protein kinase C.Am J Physiol Heart Circ Physiol,2004,286 (1):H 165-173.
  • 7Kawanabe Y,Masaki T,Hashimoto N,et al.Involvement of epidermal growth factor receptor-protein tyrosine kinase transactivation in endothelin-1-induced vascular contraction.J Neurosurg,2004,100(6):1066-1071.
  • 8Suzuki K,Meguro K,Sakurai T,et al.Endothelin-1 concentration increases in the cerebrospinal fluid in cerebral vasospasm caused by subarachnoid hemorrhage.Surg Neurol,2000,53(2):131-135.
  • 9Mascia L,Fedorko L,Stewart DJ,et al.Temporal relationship between endothelin-1 concentrations and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.Stroke,2001,32(5):1185-1190.
  • 10Kessler IM,Pacheco YG,Lozzi SP,et al.Endothelin-1 levels in plasma and cerebrospinal fluid of patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage.Surg Neurol,2005,64 Suppl 1:S1:2-5.

共引文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部