脑血栓形成患者血清脂联素、超敏C-反应蛋白变化的临床研究

Clinical study of changes of adiponectin and high Sensitivity C reactive protein in patents with Cerebral Thrombosis

目的:探讨脑血栓形成(CT)患者急性期血清脂联素与超敏C-反应蛋白(hsCRP)的变化。方法:CT患者48例(CT组),健康体检者20例为正常对照组(对照组),分别检测其血清脂联素、hsCRP水平,并比较两者的相互关系。结果:CT组血清脂联素明显低于对照组(P<0.01);hsCRP高于对照组(P<0.01),两者呈负相关(r=-0.308,P<0.05)。结论:CT患者血清脂联素水平降低,hsCRP水平增高,两者可能共同参与了动脉粥样硬化(AS)的发展过程。

Objective： To investigate the changes of serum adiponectin and high sensitivity C-reactive protein （hsCRP） in patients with acute cerebral thrombosis. Methods： Serum levels of adiponectin and hsCRP were measured in 48 patients with cerebral thrombosis （ CT group） and 20 healthy subiects served as control （control group） . Results; Serum levels of adiponectin significantly decreased （P〈0. 01）while hsCRP increased （P〈0. 01） in CT group as compared with control group. The changes of serum adiponectin and hsCRP were negatively correlated （r=-0. 308, P〈0. 05）. Conclusion;The Serum levels of adiponectin significantly decrease in CT group,which association with increased hsCRP may promote the development of atherosclerosis （AS）