3，5-二羟基联苄的合成方法改进

Synthesis of 3,5-dihydroxy-bibenzyl

目的改进3,5-二羟基联苄的合成方法。方法以3,5-二甲氧基苯甲醛为起始原料,经过Wittig反应、还原反应、脱甲基反应共3步反应得到目标化合物。结果成功地合成了3,5-二羟基联苄,总收率为88.2%。结论改进后的合成方法反应时间明显缩短,操作方法大大简化,收率由40%提高到88.2%。

Aim To improve the synthetic procedure of 3, 5-dihydroxy-bibenzyl. Methods 3, 5-dihydroxy-bibenzyl was prepared in 3 steps from starting material 3, 5-dimethoxybenzaldehyde, followed by Wittig reaction, reduction and demethylation. Results The target compound was provided in a total yield of 88.2%. Conclusion Compared with other reported methods, the operation was simplified, the reaction time was shortened and the yield was raised from 40% to 88.2%.