川崎病合并IgA肾病1例报告并文献复习

Kawasaki disease combined IgA nephropathy: a case report and literature review

目的报告1例儿童川崎病合并IgA肾病并文献复习,以提高对该病的认识和临床诊疗水平。方法根据患儿的症状、体征及心脏超声检查结果进行诊断,并结合文献资料进行分析。结果男孩,7岁,皮疹、发热后3周出现蛋白尿、镜下血尿。超声心动图(UCG)检查发现左右冠状动脉改变,肾穿刺病理报告系膜增生性IgA肾病。结论儿童川崎病合并IgA肾病比较少见,应提高认识,并进行更深入的研究。

Objectives To describe the clinical and pathological characteristics of Kawasaki disease （KD） coexisting with IgA nephropathy. Methods One case was retrospectively analyzed. The case was confirmed to have KD as well as IgA nephropathy by clinical manifestations, ultrasonography examination and renal biopsy. Results Boy of seven years old started to have heavy proteinuria, persistent microscopic hematuria three weeks after the onset of acute febrile illness with mucosal inflammation, skin rash and cervical lymphadenopathy. The uhrasonography showed the dilatation of the coronary artery. The renal biopsy revealed IgA nephropathy having mesangial proliferation with IgA deposition. Coulusions KD combined IgA nephropathy was uncommon in childhood. It is necessary to perform long-term follow-up and to further investigate the mechanisms. Early diagnosis and treatment may imorove the prognosis .