绝经后妇女年龄、绝经年限等因素与骨密度关系的探讨

The Relationship Among Menopausal Period,Number of Delivery and Bone Mineral Density with Ultrasound in Postmenopausal Women

目的探讨绝经后妇女年龄、绝经年限、初潮年龄、生育次数及哺乳时间与桡骨远端超声骨密度的关系。方法调查159名健康绝经后妇女的年龄、绝经年限、初潮年龄、生育次数、哺乳时间，测量身高、体重、桡骨远端骨密度，进行分析。结果年龄为55岁及以上的妇女与年龄〈50岁骨密度比较差异均有统计学意义（P〈0．01）。绝经年限≥10年者各组与绝经年限1—4年者比较，差异有统计学意义（P〈0．01）。哺乳时间0—16个月组与17—36个月和〉36个月组比较，差异有统计学意义（P〈0．01）。生育次数≤1次者与生育次数≥4次组比较，差异有统计学意义（P〈0．01）。单因素相关分析表明年龄、绝经年限、生育次数、哺乳时间与桡骨远端骨密度呈负相关（P〈0．01）。调整身高、体重指数后偏相关分析表明，年龄、绝经年限、生育次数、哺乳时间与桡骨远端骨密度呈负相关（P〈0．01或P〈0．05）。结论年龄、绝经年限、生育次数、哺乳时间与桡骨远端超声骨密度有关。

Objective To evaluate the relationship of age, menopausal period, age of menarche, parity and lactation and bone mineral density （BMD）.Methods Totally, 159 healthy postmenopausal women were investigated . The age, menopausal period, age of menarche, parity, lactation ,height , weight and BMD of distal radios data were collected. And the relationships among them were analysed. Results There were significantly difference in BMD between women aged less than 50 years and more than 55 years（ P 〈 0.01 ） ;BMD of distal radios were significantly increased in women with less than four years of menopausal period compared with those menostasis more than ten years（ P 〈 0.01 ） ; BMD of distal radios were significantly increased in women with less than sixteen months of loctation compared with those loctating more than thirty-six months（ P 〈 0.01 ） ;BMD of radio-distant were significantly increased in women who had one delivery compared with women having more than four deliveries（ P 〈 0.01）. Correlation analysis showed that the age, menopausal period, the number of delivery, months of loctation were negatively correlated with BMD（ P 〈 0.01 ）, but the age of menarche was not （ P 〉 0.05） .After adjustment of the height and BMI, the BMD of radio-distant was negatively correlated with the age, menopausal period , the number of delivery（ P 〈 0.01 ）, but the age of menarche was not （ P 〉 0.05）. Conclusion The age, menopausal period, the number of delivery and loctation are associated with BMD of distal radios.