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α7烟碱型乙酰胆碱受体在老年痴呆疾病中的作用

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作者 苗珍花 田建英
机构地区 宁夏医学院基础学院解剖学教研室
出处 《宁夏医学院学报》 2008年第2期253-256,共4页 Journal of Ningxia Medical College
基金 国家教育部优秀青年教师资助项目:教人司(2002-350号) 国家中医药管理局项目(04-05zp62)
关键词 Α7烟碱型乙酰胆碱受体 老年痴呆 研究进展
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献25

  • 1Belluardo N,Mudb G,Blum M,et al.Central nicotinic receptors,neurotrophic factors and neuroprotection[J].Behav Brain Res,2000,113:21-34.
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  • 3JL Galzi,D Bertrand,A Devillers-Thiery,et al.Functional significance of aromatic amino acids from three peptide loops of the alpha7 neuronal nicotinic receptor site investigated by site-directed mutagenesis[J].FEBS Lett,1991,294(3):198-202.
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  • 7Donna L,Herber,Emily G,et al.Biochemical and Histochemical Evidence of Nonspecific Binding of α7 nAChR Antibodies to Mouse Brain Tissue[J].Journal of Histochemistry,2004,52(10):1367-1375.
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二级参考文献13

  • 1Liu Q, Kawai H, Berg DK. Beta-Amyloid peptide blocks the response of alpha7 contamng nicotinic receptors on hippocampal neurons[J]. Proc Natl Acad Sci USA,2001,98:4734-4739
  • 2Elliott KJ, Ellis SB, Berckhan K J, et al. Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta2 and beta4 subunits[J]. J Mol Neurosci,1996,7:217-228
  • 3Gault J, Robinson M, Berger R, et al. Genomic organization and partial duplication of the human alpha 7 neuronal nicotinic acetylocholine receptor gene[J]. Genomics, 1998,52:173-185
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  • 6Elmslie FV, Rees M, Williamson MP, et al. Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q[ J].Hum Mol Genet, 1997,6:1329-1334
  • 7Free dman R, Coon H, Myles-Worsley M, et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus[J].Proc Natl Acad Sci USA, 1997,94:587-592
  • 8Freedman R, Hall M, Adler LE, et al. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic reeptors in schizophrenia[J]. Biol Psychiat, 1995,38:22-33
  • 9Guan ZZ, Zhang X, Ravid R, et al. Decreased protein levels of ricotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease[J]. J Neurochem,2000,74:2.37-243
  • 10Burghaus L, Schutz U, Krempel U, et al. Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients[J]. Brain Res Mol Brain Res,2000,76:385-388

共引文献1

宁夏医学院学报
2008年 第2期

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