Morquio A综合征的诊断研究 Ⅳ.诊断和产前诊断方法的建立

Fluorimetric Enzymatic Diagnosis of Morquio A Syndrome Ⅳ. Development of Conditions for the DiagnosticEnzyme Assay

本文进一步研究了Gal-6S在不同离子强度和抑制剂等的影响下的酶动力学。利用外周血白细胞和培养的成纤维细胞建立了生后诊断方法。利用培养的羊水细胞和绒毛细胞以及绒毛组织和胚胎组织建立了产前诊断方法。

After studying the effects of inhibitors and ionic strength on Gal-6S activity, we defined conditions for the postnatal diagnosis with leucocytes and fibroblasts, prenatal diagnosis with amniocytes, chorionic villus cells, chorionic villi and fetal tissues.