肝癌组织细胞骨架连接蛋白和焦点黏附激酶的表达及其意义

Significance of Ezrin and FAK exppression on hepatocellular carcinoma

目的:检测细胞骨架连接蛋白(membrane cytoskeleton cross linker protein,Ezrin)、焦点黏附激酶(focal ad-hesion kinase,FAK)在肝癌组织中的表达及其临床意义。方法:手术切除肝癌标本79例(其中62例附癌旁正常组织),应用免疫组化检测Ezrin,FAK的表达。结果:免疫组化染色显示,Ezrin和FAK的表达与肝癌的浸润、转移呈正相关,与分化程度呈负相关(P<0.05)。结论:Ezrin,FAK的高表达与肝细胞癌的侵袭转移关系密切,它们可能是影响肝癌患者预后以及癌细胞转移的重要因素。

Objective： To investigate the expression of Ezrin and FAK in hepatocellular carcinoma, as well as to elucidate its clinical significance. Methods： Immunohistochemical technique was used to detect the expression of Ezrin,FAK in 79 cases of hepatocellular carcinoma and 62 cases of adjacent hepatic tissue. Results： Ezrin and FAK over-expression was positively correlated with the metastasis and was inversely correlated with the cancer differentiation level （ P 〈 O. 05 ）. Conclusion： The up-regulation of Ezrin and FAK may contribute to carcinogenesis and progression of hepatocellular carcinoma.