肝干细胞来源的研究进展

Progress on the origin of hepatocyte stem cell

从广义上讲，肝干细胞并非特指某一类细胞，而是与肝脏胚胎发育及再生有关的各类具有干细胞特性细胞类型的总称，是一种具有分化为成熟肝细胞和胆管细胞能力和自我更新能力的多潜能干细胞。根据其起源的不同，通常可分为肝源性肝干细胞和非肝源性肝干细胞。

Generally speaking, the hepatocyte stem cell is not a specific cell type, but an overall name of all kinds of cells that possess stem cell characters about embryonic development and regeneration of liver. HSC is a pluripotential stem cells which have self-renewal capacity and could differentiate into mature hepatocytes and bile duct cells. According to the different origin of hepatocyte stem cell, it can be usually divided into two kinds： non liver-derived hepatocyte stem cell and liver-derived hepatocyte stem cell.