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结肠癌基因治疗安全性研究进展 被引量:2

Advance in safety of genetherapy in colon cancer
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摘要 目前,结肠癌的治疗手段主要以手术为主,辅以全身或局部放疗、化疗。随着分子生物学的发展,结肠癌的基因治疗出现了多种治疗方案,其中有些方法已获准进入临床试验阶段。但是,对结肠癌基因治疗的安全性仍是研究热点。 Surgical treatment of colon cancer is the first choice in the therapy stages, supplemented with systemicor local radiotherapy and chemotherapy. With the developement of molecular biology, there has been a variety of treatment program, some of these methods have been accepted in clinical testing stage. But the safety of the treatment on colon cancer is still a hot topic.
出处 《国际外科学杂志》 2008年第4期254-256,共3页 International Journal of Surgery
基金 福建省自然科学基金资助项目(No.C0410045)
关键词 结肠癌 基因治疗 安全性 colon cancer cene therapy safety
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  • 1韩德民,黄志刚,张伟,于振坤,王琪,倪鑫,陈晓红,潘锦华,王鸿.重组人p53腺病毒注射液治疗喉癌的Ⅰ期临床试验及追踪观察[J].中华医学杂志,2003,83(23):2029-2032. 被引量:60
  • 2Englehardt JF, Litzky L, Wilson JM. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a[J]. Hum Gene Ther, 1994, 5: 1217-1229.
  • 3Raper SE, Haskal ZJ, Ye X, et al. Selective gene transfer into the liver of non-human primates with El-deleted, E2A-defective, or Ei-FA-deleted recombinant adenoviruses [ J ]. Hum Gene Ther,1998, 9: 671-679.
  • 4Sullivan DE, Dash S, Du H, et al. Liver-directed gone transfer in non-human primates[ J]. Hum Gene Ther, 1997, 8 : 1195-1206.
  • 5Graham FL, Prevec L. Gene transfer and expression protocols[ M ]. In : Murray ZJ ed. Methods in molecular biology, Vol 7,humane Press Inc, Clifton, 1991, 109-128.
  • 6Li Q, Kay MA, Fiengold M, et al. Assessment of recombinant adenoviral vectors for hepatic gene therapy [ J ]. Hum Gene Ther,1993, 4: 403-409.
  • 7Kozarsky KF, Mckinley DR, Austin LL, et al. in vivo correction of low density lipoprotein receptor deficiency in the wantanabe heritable hyperlipidemic rabbit with recombinant adenoviruses[ J ]. J Biol Chem, 1994, 269: 13695-13702.
  • 8Jaffe HA, Danier D, Longenecker M, et al. Adenoviral-mediated in vivo gene transfer and expression in normal rat liver [ J ]. Nat Genet, 1992, 1: 372-378.
  • 9Dai Y, Schwarz EM, Gu D, et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression[J]. Proc Natl Acad Sci U S A, 1995, 92: 1401-1405.
  • 10Dai Y, Schwarz EM, Gu D, et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression[J]. Proc Natl Aead Sci U S A, 1995, 92: 1401-1405.

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  • 1李鹏,刘江伟,许永华,张东辉,李建瑛,张燕,张淑鹏.不同新生牛血清对胰腺癌BxPC-3细胞增殖的影响[J].中华临床医师杂志(电子版),2011,5(17):5009-5012. 被引量:4
  • 2Jemal A,Siegel R,Ward E,et al.Cancer statistics,2009[J].CA Cancer J Clin,2009,59(4):225-249.
  • 3Colussi D,Brandi G,Bazzoli F,et al.Molecular pathways involved in colorectal cancer:implications for disease behavior and prevention[J].Int J Mol Sci,2013,14(8):16365-16385.
  • 4Manzano A,Péerez-Segura P.Colorectal cancer chemoprevention:is this the future of colorectal cancer prevention[J].Scientific World Journal,2012,2012:327341.
  • 5Venkatesan P,Bhutia SK,Singh AK,et al.AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells[J].Life Sci,2012,91 (15/16):789-799.
  • 6van Heumen BW,Roelofs HM,Te Morsche RH,et al.Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells[J].Exp Cell Res,2012,318(7):819-827.
  • 7Vaish V,Sanyal SN.Role of sulindac and celecoxib in the regulation of angiogenesis during the early neoplasm of colon:exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/β-catenin signaling[J].Biomed Pharmacother,2012,66(5):354-367.
  • 8Benelli R,Venè R,Minghelli S,et al.Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts,activating erk1-2 signaling in synergy with EGFR[J].Cancer Lett,2013,328(1):73-82.
  • 9Ambrosini G,Adida C,Altieri DC.A novel anti-apoptosis gene,Survivin,expressed in cancer and lymphoma[J].Nat Med,1997,3(8):917-921.
  • 10Tamm I,Wang Y,Sausville E,et al.IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95),Bax,caspases,and anticancer drugs[J].Cancer Res,1998,58(23):5315-5320.

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