肺癌治疗与真菌感染相关性分析

Analysis of correlation between lung cancer treatment and fungal infection

目的探讨肺癌治疗与真菌感染之间的关系。方法2083例肺癌患者按治疗方法分别进行分组，包括手术与非手术组，放疗组、化疗组和放疗化疗组，治疗感染组和预防感染组。分析各治疗方法中导致真菌感染因素并做统计学处理。结果肺癌患者的真菌感染率14.16％，手术组与非手术组感染率无统计学意义（P〉0.05），手术组内Ⅲ、Ⅳ期之间有统计学意义（P〈0.01），Ⅲ、Ⅳ期手术组和非手术组有统计学意义（P〈0.01），化疗组，放疗化疗组与放疗组有统计学意义（P〈0.05），化疗组和放疗化疗组无统计学意义（P〉0.05），治疗感染组和预防感染组有统计学意义（P〈0.05），治疗感染组和预防感染组内随着联合用药的增加差异有统计学意义（P〈0．01）。结论肺癌患者Ⅲ、Ⅳ期手术，化疗，联合应用抗生素，激素、导管侵入治疗可增加其真菌的感染率。

Objective To analyze the correlation between lung cancer treatment and fungal infection. Methods Altogether 2083 patients with lung cancer were enrolled in this retrospective study. The patients were classified by methods of therapy, including operative group and non-operative group, antibiotic group and nonantibiotic group, radiotherapy group, chemotherapy group, radiochemotherapy group, hormone group and catheter therapy group. Results Out of the 2083 patients, 14. 16% were diagnosed of airway fungal infection. The difference of infection rate was not significant between operation group and non-operation group （P 〉 0. 05）. Among the operation group, the Ⅳ phase cancer patients had significantly higher infection rate than Ⅲ phase patients （P〈0. 01）. The patients who had received chemotherapy, or combination of chemotherapy and radiotherapy had a higher infection rate than those who received radiotherapy only （ P 〈 0. 05 ）. Those who received antimicrobial treatment had a higher infection rate than those who received antimicrobial prophylaxis （ P 〈 0. 05 ）. Specifically, the more antimicrobials was used, the more significant the difference was （P 〈 0. 01 ）. Conclusion The incidence of fungal infection in lung cancer patients is related to the use of antibiotics, chemotherapy, operation, hormone therapy and catheter therapy.