系统性红斑狼疮的心脏损害及其与抗dsDNA抗体间的关系

Cardiac Manifestations of SLE and Their Relation with Antibodies to dsDNA

本文探讨了147例SLE病人的心脏表现特点及其与抗dsDNA抗体间的关系。结果表明,SLE有心脏损害的占59%(87╱147)。血清中抗dsDNA抗体水平(25.10)显著高于无心脏损害的SLE病人(17.20),p<0.001。前者抗dsDNA抗体结合率>20%的占55%,后者占36%,P<0.05。我们推论,SLE病人半数以上有不同程度的心脏损害,免疫因素可能起重要作用。

The cardiac manifestations in 147 patients with SLE were observed. The results showed that 87 of 147 Patients were involved in the heart (59%), including 14 Pericarditis(10%), 19 myocarditis(13%), one coronary artery disease and one mitral stenosis. The serum antibodies levels against dsDNA in SLE Patients with cardiac abnormalities were higher than in those without cardiac disorders(P<0.001). Fifty five percent of patients in the former had raised antibodies levels(DNAbinding>20%), compared with 38% in the latter(P<0.05). We conclude that most patients with SLE suffered from the cardiac abnormalities with different degrees and it often occured in the active stage of disease. Immunology factors may play an important role for them.