老年患者全凭静脉麻醉术前静脉应用长托宁或阿托品的比较

Comparison of Penehyclidine Hydrochloride and Atropine used as premedication of total intravenous general anesthesia in elder patients

目的对长托宁和阿托品作为老年全凭静脉麻醉术前静脉用药进行随机双盲比较。方法60例行腹部手术的老年患者,随机均分为两组,分别于入室后静脉给予长托宁0.012mg/kg(A组)或阿托品0.008mg/kg(B组),观察注药后10、20、30min的血压、心率、脉氧饱和度,口干程度,及镇静程度。结果2组病人年龄、性别、体重和身高差异均无显著性(P>0.05);A组心率无明显变化(P>0.05),B组心率与基础值比较明显增快(P<0.05),B组口干程度与基础值比较明显增强(P<0.05),但口干程度两组间差异无显著性(P>0.05),A组镇静作用优于B组(P<0.05)。结论长托宁具有很好的抑制腺体分泌作用、维持心血管功能稳定和良好的中枢镇静作用,能有效预防术中知晓,是理想的老年患者术前用药。

[Objective] To compare the effects of Penehyclidine Hydrochloride and Atropine in terms of premedication in total intravenous general anesthesia of elder patients. [Methods] Sixty who received elder patients abdominal sugery were randomly allocated into two group equally： group A were given penehyclidine hydrochloride 0.012 mg/kg iv; group B were given atropine 0.008 mg/kg iv, blood pressure, heart rate, SpO2, oral dryness condition and the level of sedation were monitored in 10, 20, 30 min after administration. [Result] There were no significant differences of age, sex, body weight and height beteew the two groups （P 〉0.05）. In group A, there was no obvious change in heart rate（P 〉0.05）; in group B heart rate increased severely compared with the basic value, the same was true for oral dryness（P〈0.05）, but there was no difference between the two groups in oral dryness（P〉0.05）. Group A＇ s sedation was better than group B（P 〈0.05）. [ Conclusion] Penehyclidine Hydrochloride has effects of inhibiting secretion of salivary glands, maintaining cardiovascular stability and central nervous system sedation, helps to prevent awareness during operation, so it is ideal premedication for elder patient.