施今墨验方加减治疗多囊卵巢综合征合并2型糖尿病的临床研究

The study on traditional Chinese medicine in the treatment of 2 cases of polycystic ovary syndrome complicated with 2-type diabetes mellitus

目的观察施今墨验方加减治疗多囊卵巢综合征（PCOS）合并2型糖尿病的临床疗效。方法将53例多囊卵巢综合征合并2型糖尿病患者随机分为2组。治疗组27例予施今墨验方加减，日1剂，水煎分2次服。对照组26例予二甲双胍500mg，每日3次餐前口服。2组均1个月为1个疗程，连续治疗3～6个疗程。判定2组临床疗效，并观察2组治疗前后空腹血糖、月经情况及血生殖激素变化。结果治疗组总有效率92．59％，对照组总有效率65．38％，2组比较差异有统计学意义（P〈0．05）。2组治疗后空腹血糖与本组治疗前比较差异有统计学意义（P〈0．05），2组治疗后空腹血糖比较差异有统计学意义（P〈0．05）。2组月经不规律阴转率比较差异有统计学意义（P〈0．05）。2组治疗后睾酮。

Objective To investigate the TCM pathogenesis of polycystic ovary syndrome （PCOS） complicated with 2 - type diabetes mellitus, and to observe the clinical efficacy. Mehods 53 patients with PCOS complicated with 2 - type diabetes mellitus were randomly divided into two groups. 27 patients in treatment group were treated with traditional Chinese herb decoction, one dose a day for twice administration; 26 patients in control group were treated with mefformin , 500mg once, 3 times a day, taken before meal, with a treatment course of one month for both groups. The therapeutic effects were observed after 3 - 6 treatment courses. Results The total effective rate in treatment group was 92.59 %, which was 65.38 % in control group. There was a sigfificant difference between two groups（ P 〈0.05）. Conclusion The traditional Chinese medicine is effective in treating PCOS complicated with 2 - type diabetes mellitas, which is worth to be bread in clinic.