烧伤科患者感染病原菌的变迁及抗菌药物耐药性分析

Change in Bacterial Flora and Antibiotic Resistance of Bacteria of Burn Patients

目的了解烧伤科患者感染病原菌及对抗菌药物耐药性的变迁,以防耐药菌株的产生,为临床诊治提供参考依据。方法对1996年6月-2001年5月(第1组)及2001年6月-2006年6月(第2组)两个时期的烧伤患者进行创面培养病原菌检出情况及药敏结果调查。结果在第2组中铜绿假单胞菌仍居首,占30.0%;金黄色葡萄球菌居第2位,占28.2%;其中G-杆菌占58.2%,G+球菌占40.3%;奇异变形菌、鲍氏不动杆菌、粪肠球菌以及白色假丝酵母菌有明显上升;铜绿假单胞菌、阴沟肠杆菌、大肠埃希菌对第三代头孢菌素的耐药率较前5年有明显上升。结论烧伤科患者感染病原菌耐药性变迁与头孢类抗菌药物及亚胺培南等广谱抗菌药物广泛应用有一定关系。

OBJECTIVE To investigate and analyze the pathogenic bacteria of burn infection and their drug resistance in recent 5 years from 2001.METHODS The patients were divided into two groups.The group 1 included patients from Jun 1996 to May 2001 and the group 2 was from Jun 2001 to Jun 2006.Burn wound bacteria were cultured,and identified and their drug sensitivity was analyzed.RESULTS In burn wound culture,in group 2 Pseudomonas aeruginosa with the rate of 30% was still in the 1st place.Staphylococcus aureus was in the 2nd place with the rate of 28.2%.The G^-bacilli comprised 58.2% and the G^＋ cocci 40.3 %.Proteus mirabilis,Acinetobacter baumannii,Enterococcus faecalis and Candida albicans increased remarkably.The drug resistant percentage of P.aeruginosa,Enterobacter cloacae and Escherichia coli to third generation cephalosporin increased greatly.CONCLUSIONS The changes of pathogenic bacteria of burn infection and bacteria drug resistance have certain relations with the wide usage of broad spectum antibiotics such as cephalosporin and imipenem.