医院感染大肠埃希菌的药敏试验分析

Escherichia coli Drug Sensitivity Analysis in Hospital Infection

目的调查分析感染大肠埃希菌的菌群分布、结构和耐药现状,指导临床合理使用抗菌药物。方法从2005年11月-2006年12月,对2940份各类标本中分离出大肠埃希菌247株,采用常规法鉴定菌种,用K-B法进行病原菌药敏及耐药试验并进行分析。结果对医院感染的大肠埃希菌标本做药敏试验,药物敏感率排在前6位为,头孢哌酮/舒巴坦86.84%、呋喃妥因55.56%、氯霉素43.75%、阿米卡星40.43%、头孢曲松27.41%、头孢哌酮27.16%;对大肠埃希菌耐药率排在前6位为复方新诺明93.33%、氨芐西林93.18%、阿莫西林92.00%、头孢氨苄90.00%、头孢噻吩86.67%、头孢拉定85.03%。结论加强抗菌药物的药敏试验,能及时采取有效的对应治疗方法和措施,为临床医生指导合理使用抗菌药物提供科学依据。

OBJECTIVE To survey the Escherichia coli infection in our hospital in the field of flora distribution,structure and status quo resistance in order to guide the rational use of antibiotics.METHODS From Nov 2005 to Dec 2006 247 E.coli strains were isolated from 2940 samples with conventional method identification,K-B method was used for bacterial susceptibility,and resistance test.RESULTS The top six susceptible antibiotics were cefoperazone/sulbactam（86.84%）,nitrofurantoin（55.56%）,chloramphenicol（43.25%）,amikacin（40.43%）,ceftriaxone（27.41%）,and cefoperazone（27.16%）.The top six resistant antibiotics were sulfamethoxazole/trimethoprim Co-trimoxazole（93.33%）,ampicillin（93.18%）,amoxicillin（92.00%）,cefalotin（86.67%）,cefradine（85.03%）,and cefuroxime（81.25%）.CONCLUSIONS Strengthening antibacterial drug sensitivity test,and conduct ing timely the effective treatment and corresponding measures could guide the clinician to provide a reasonable use of antibiotics.