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非酒精性脂肪性肝病大鼠解偶联蛋白2的表达及其与胰岛素抵抗的关系 被引量:1

Relationship between the expression of uncoupling protein 2 and insulin resistance in fatty liver rats induced by high-fat food
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摘要 本研究通过高脂饮食喂养大鼠,观察大鼠肝内脂肪沉积情况,同时检测肝细胞解偶联蛋白2(UCP-2)和胰岛素信号分子胰岛素受体底物2(IRS-2)mRNA的表达,以探讨在非酒精性脂肪性肝病(NAFLD)发病中胰岛素抵抗与肝细胞UCP2表达的关联及其作用机制。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2008年第4期311-312,共2页 Chinese Journal of Hepatology
基金 基金项目:湖北省自然科学基金(2005ABA158)
关键词 脂肪肝 胰岛素抗药性 解偶联蛋白2 Fatty liver Insulin resistance Uncoupling proteins 2
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参考文献5

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二级参考文献9

  • 1范建高,郑晓英,张梅,曹中伟,丁晓东.非酒精性脂肪性肝病大鼠肝脏纤溶酶原激活物及其抑制物mRNA表达[J].肝脏,2004,9(2):103-105. 被引量:6
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共引文献20

同被引文献11

  • 1高志强,陆付耳,董慧,徐丽君,王开富,邹欣.二甲双胍干预高脂饲养所致大鼠脂肪肝的研究[J].中华肝脏病杂志,2005,13(2):101-104. 被引量:22
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  • 9林海凤,林志辉.PPARγ、UCP2与非乙醇性脂肪性肝病[J].医学综述,2008,14(4):496-498. 被引量:1
  • 10李光伟.2型糖尿病系列讲座 第三讲:胰岛素敏感性评估及其在临床研究中的应用[J].中华内分泌代谢杂志,2000,16(3):198-200. 被引量:195

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