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环氧合酶-2在非酒精性脂肪肝中的表达及其致病的可能机制 被引量:2

An experimental study on the expression and pathogenic effects of cyclooxygenase-2 in nonalcoholic fatty liver disease
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摘要 环氧合酶-2(COX-2)的过度表达与许多炎症性疾病有关,然而对它在非酒精性脂肪肝(NAFLD)中的表达和作用机制知之甚少。Celecoxib是特异性的COX-2抑制剂。我们通过建立大鼠NAFLD动物模型,同时在模型组中给予celecoxib进行干预治疗,研究COX-2在NAFLD中的作用,以便进一步探讨其在NAFLD中的致病机制。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2008年第4期315-316,共2页 Chinese Journal of Hepatology
关键词 脂肪肝 环氧合酶-2 白细胞介素-1 Fatty liver Cyclooxygenase-2 Interlukin-1
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参考文献5

  • 1中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊断标准[J].中华肝脏病杂志,2003,11(2):71-71. 被引量:1368
  • 2祁培宏,余莉芳,刘平.消脂保肝饮抗大鼠脂肪肝作用的研究[J].中西医结合肝病杂志,2000,10(5):33-35. 被引量:41
  • 3Grant LM, Lisker-Melman M. Nonalcoholic fatty liver disease. Ann Hepatol, 2004, 3: 93-99.
  • 4Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology, 2003, 37: 1202-1219.
  • 5Yu J, Ip E, Dela Pena A, et al. COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. Hepatology, 2006, 43:826-836.

二级参考文献3

共引文献1407

同被引文献20

  • 1周筱艳,阳学风.环氧合酶-2抑制剂尼美舒利对大鼠肝纤维化的影响[J].中华消化杂志,2004,24(7):441-442. 被引量:5
  • 2Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association..非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志,2006,14(3):161-163. 被引量:1512
  • 3舒建昌,潘洁,沈雁,何雅军.环氧合酶-2抑制剂联用姜黄素对肝星状细胞增殖抑制作用的观察[J].广东医学,2006,27(8):1142-1144. 被引量:3
  • 4Courivaud C,Bamoulid J,Tiberghien P,et al.G-765C COX-2 gene promoter polymorphism and risk of atherosclerosis after kidney transplantation.Transplantation,2009,88:851-852.
  • 5Pandey S,Mittal RD,Srivastava M,et al.Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian population.Int J Gynecol Cancer,2010,20:625-630.
  • 6Koopmann J,Rosenzweig CN,Zhang Z,et al.Serum markers in patients with resectable pancreatic adenocarcinoma:macrophage inhibitory cytokine i versus CA19-9.Clin Cancer Res,2006,12:442-446.
  • 7Lowenfels AB,Maisonneuve P,Whitcomb DC,et al.Cigarette smoking as a risk factor for pancreatic cancer ia patients with hereditary pancreatitis.JAMA,2001,286:169-170.
  • 8Grφnborg M,Bunkenborg J,Kristiansen TZ,et al.Comprehensive proteomic analysis of human pancreatic juice.J Proteome Res,2004,3:1042-1055.
  • 9Nanji AA,Miao L,Thomas P,et al.Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat.Gastroenterology,1997,112:943-951.
  • 10Enomoto N,Ikejima K,Yamashina S,et al.Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver.Am J Physiol Gastrointest Liver Physiol,2000,279:G100-106.

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