普罗布考对脑梗死患者急性期血清MMP-9水平的影响

Effect of probucol on the level of MMP-9 in acute stage of cerebral infarction

目的观察普罗布考对脑梗死患者急性期血清基质金属蛋白酶9(matrix metalloproteinases9,MMP-9)水平的影响。方法采用自身对照和组间对照,将62例急性期脑梗死患者分为2组,其中普罗布考组(32例),常规治疗组(30例),用酶谱法分别测定治疗前后血清MMP-9水平的变化。结果(1)普罗布考组治疗2周后血清MMP-9水平较治疗前明显降低(P<0.05),而常规治疗组治疗前后血清MMP-9水平无明显差异(P>0.05);(2)治疗2周后普罗布考组血清MMP-9水平较常规治疗组明显降低(P<0.05)。结论普罗布考能降低脑梗死患者急性期血清MMP-9水平,可能因此抑制了血-脑屏障的早期开放和脑水肿,从而减轻缺血性脑损伤,防止脑梗死出血转化和再发。

Objective To observe the effect of probucol on the level of MMP-9 in acute stage of cerebral infarction. Methods Using a random and single blind control test, 62 patients with cerebral infarction in acute stage were assigned into probucol group （n = 32） and control group （n = 30）. With the method of SDS-Page zymograph, the levels of MMP-9 in serum were measured before and after therapy. Results （ 1 ） After 2 weeks of follow-up, the level of MMP-9 in serum was lower （P〈0. 05） in the probucol group than that in control group. （2） The level of MMP-9 in serum was lower （P〈0. 05） in the probucol group than that in control group after two-week therapy. Conclusions Probucol can reduce the level of MMP-9 in acute stage of cerebral infarction, thus may relieve the ischemic brain injury.