雷公藤多甙对哮喘大鼠血清及肺组织NO含量和总抗氧化能力的影响

Effect of tripterygium wilfordii on nitric oxide and total antioxidative capability in serum and lung tissues of asthma rats

目的观察雷公藤多甙对哮喘大鼠血清及肺组织一氧化氮(NO)含量和总抗氧化能力(T-AOC)的影响。方法雄性Wistar大鼠36只,体重200g左右,随机分为对照组、哮喘组和雷公藤干预组。测量各组大鼠血清及肺组织NO含量和T-AOC。结果哮喘组大鼠血清及肺组织NO含量显著高于对照组和雷公藤干预组(均P<0.05),而雷公藤干预组显著高于对照组(均P<0.05)。哮喘组大鼠血清及肺组织T-AOC较对照组和雷公藤干预组降低,差异有统计学意义(均P<0.05),但雷公藤干预组显著低于对照组(P<0.05)。结论雷公藤多甙能提高哮喘大鼠体内的抗氧化能力,这种作用可能是通过抑制哮喘大鼠气道NO的合成实现的。

Objective To explore the effect of tripterygium wilfordii（TW） on nitric oxide and total antioxidative capability in serum and lung tissues of asthma rats. Methods Thirty-six Wistar male rats were randomly divided into control group,asthma group and TW treated group. NO concentration and total antioxidative capability in serum and lung tissues of asthma rats were detected. Results The NO concentration in serum and lung tissues in asthma group were significantly higher than in control group and TW treated group（P 〈0.05）,but total antioxidative capability in asthma group were significantly lower than in control group and TW treated group（P〈0.05）. The NO concentration in serum and lung tissues in TW treated group were higher than in control group （P 〈0.05）, while total antioxidative capability in serum and lung tissues were significantly lower than in control group（ P 〈 0.05）. Conclusion Tripterygium wilfordii may enhance antioxidative capability in asthma rats through reducing NO concentration.