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雌激素对Wistar大鼠实验性变态反应性脑脊髓炎的治疗作用 被引量：2

Therapeutic Effects of Estrogen in Experimental Autoimmune Encephalomyelitis in Rats
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摘要 目的探讨雌激素对大鼠实验性变态反应性脑脊髓炎(EAE)的治疗作用。方法去卵巢模型组采用豚鼠髓鞘蛋白和完全福氏佐剂诱发去卵巢大鼠;治疗组在去卵巢模型组的基础上予以不同剂量雌激素观察各组的发病情况;HE染色观察病理变化。结果低剂量组EAE临床症状较去卵巢模型组轻;高剂量组未出现临床症状;脑和脊髓炎症细胞浸润明显减少。结论雌激素对EAE有治疗作用并与剂量相关。 Objective To investigate the therapeutic effect of estrogen on experimental autoimmune encephalomyelitis（EAE）in Wistar rats. Methods The animal models were established in ovariectomized 36 rats by immunization with myelin basic protein of spinal cord of guinea pig and complete Freund＇s adjuvant and divided into three groups： Control group （n=12）, low dosage of estrogen group （n=12） and high dosage of estrogen group （n=12）. The symptoms in each group were observed and pathological changes of brain and spinal cord were analyzed by hemetoxylin and eosin staining. Results There were no symptoms in high dosage of estrogen group. In low dosage of estrogen group, the symptom of EAE was lighter than that in the control group, and infiltration of inflammatory cell in brain and spinal cord decreased significantly. Conclusion Estrogen had dose-dependent therapeutic effect on the EAE.
作者 张文雁 刘春云 孟健 纪宁 尉杰忠 梁丽云 马存根
机构地区 山西医科大学第一医院 山西大同大学脑科学研究所
出处 《中西医结合心脑血管病杂志》 2008年第4期430-431,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 国家人口和计划生育委员会科研基金项目<雌激素对EAE大鼠ICAM-1 IFN-γ和BBB作用的研究> 人事部2006年度回国人员科技活动择优资助项目<雌激素对ICAM-1 IFN-γ和BBB作用的研究(国人厅发[2006]164号)>
关键词 髓鞘碱性蛋白 多发性硬化 雌激素 实验性免疫性脑脊髓炎 myelin basic protein multiple sclerosis estrogen experimental autoimmune encephalomyelitis
分类号 R744 [医药卫生—神经病学与精神病学]
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参考文献9

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同被引文献21

  • 1王雪琼,周鸿敏,阎冀焕,袁劲,周洁,唐莉,陈忠华.雌激素对同种抗原刺激T细胞反应的影响[J].中国现代医学杂志,2006,16(6):829-832. 被引量：9
  • 2吕学文,伍昌林,刘仿.CD4^+CD25^+调节性T细胞在自身免疫病中作用的研究进展[J].国际免疫学杂志,2006,29(5):287-290. 被引量：9
  • 3Ghezzi A,Zaffaroni M.Famale-specific issues in multiple sclerosis.Expert Rev Neurother,2008,8(6):969-977.
  • 4Zoller AL,Kersh CJ.Estrogen induces thymic atrophy by eliminating early thymic progenitors and inhibiting proliferation of beta-selected thymocytes.J Immunol,2006,176(12):7371-7378.
  • 5Ifergan I,Kebir H.,Wosik K,et al.The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.Brain,2008,131(pt3):785-799.
  • 6Jiang B.Estrogen modulates bone marrow-derived DCs in SLE murine model-(NZB x NZW) F1 female mice.Immunol Invest,2008,37(3):227-243.
  • 7Vegeto E,Belcredito S,Ghisletti S,et al.The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation.Endocrinology,2006,147(5):2263-2272.
  • 8Vlotides G,Gaertner R,Angstwurm MW.Modulation of monocytic lipopolysaccharide-induced tissue factor expression and tumor necrosis factor alpha release by estrogen and calcitriol.Hormones (Athens),2007,6(1):52-61.
  • 9Tripanichkul W,Sripanichkulchai K,Finkelstein DI.Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication.Brain Res,2006,1084 (1):28-37.
  • 10Bebo BF Jr,Dehghoni B,Foster S,et al.Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmue encephalomyelitis.Glia,2009,57(7):777-790.

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中西医结合心脑血管病杂志
2008年 第4期

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