重症感染患者外周血CD14^＋单核细胞HLA—DR抗原的表达意义

Expression of CD14^＋ monocyte human leukocyte antigen HLA-DR in patients of myasthenia infection

目的探讨重症感染患者外周血CD14^＋单核细胞表面HLA-DR抗原的表达。方法用流式细胞术（FCM）对加名健康体检者及59例重症感染患者外周血CD14^＋单核细胞表面HLA-DR的表达进行检测并比较。结果重症感染患者外周血CD14^＋单核细胞表面HLA-DR阳性百分率较正常对照组显著降低，经统计学分析，差异有统计学意义（P〈0．01）。结论重症感染患者外周血CD14^＋单核细胞表面HLA-DR表达量显著降低，提示患者处于免疫抑制状态。检测外周血CD14^＋单核细胞表面HLA-DR的表达量，对于临床上的药物治疗和免疫调理都有着重大的指导意义。

Objective To explore the expression and the change about HLA-DR antigen on the surface of the peripheral blood＇s CD14^＋ monocyte in the patients of myasthenia infection. Method By using the single-labeled flow cell technology, the expression about the HLA-DR antigen on the surface of the peripheral blood＇s CD14^＋ monocyte in the myasthenia infection patients were detected and compared. Results The positive incidence about HLA-DR antigen on the surface of the peripheral blood＇s CD14^＋ monocyte in the myasthenia infection patients was obviously reduced, compared to the contrast group（ P 〈 0.01 ）. Conclusions The amount of expression about HLA-DR antigen on the surface of the peripheral blood＇s CD14^＋ monocyte in the myasthenia infection patients is obviously reduced.