乙型肝炎病毒前S1抗原在核苷类药物抗病毒治疗上的意义

Significance of Pre-S1 antigen detection in evaluation of antiviral therapy by nucleotide analogs

目的研究HBV前S1抗原（Pre-S1）在指导核苷（酸）类药物抗病毒治疗上的意义。方法将HBe舷阳性患者经拉米夫定治疗获得完全应答并维持疗效6个月以上停药者以Pre-S1是否阳性分成两组，比较两组的远期疗效。结果Pre-S1阴性组一年、二年远期持续应答率分别为80％、21．05％，差异有统计学意义（P〈0．01）。阳性组患者一年、二年远期持续应答率分别为65％、10．53％，差异有统计学意义（P〈0．01）。结论检测Pre-S1可作为判断慢性乙型肝炎患者经核苷（酸）类药物治疗完全应答后远期疗效和预后的重要指标。

Objective To evaluate the significance of HBV Pre-S1 antigen detection in clinical evaluation of antiviral therapy by nucleotide analogs. Method HBeAg positive patients which had combined complete response and sustained for 6 months after lamivudine therapy were divided into two groups according Pre-S1 detection and their therapeutic effect was compared. Results The response rates of one year and two year of HBV Pre-S1 antigen positive and negative were 80% and 21.05% respectively, and showed statistical difference（ P 〈0.01）. The response rates of one year and two year of HBV Pre-S1 antigen negative were 65% and 10.53% respectively, and showed statistical difference（ P 〈 0.01 ）. Conclusions The detection of HBV Pre-S1 antigen may become an index that judges long-term effect of chronic hepatitis patients after nucleotide analogs therapy.